Synthesis and spectral characterization of curcumin and related curcuminoids

Abstract In this research work various curcuminoids have been synthesized and characterized, as the first step curcumin was synthesized from Acetyl acetone and vanillin and then the corresponding curcumin derivatives weresynthesized by treating curcumin with epichlorhydrin and K2CO3 in DMF and then its amine derivative was synthesized by refluxing with methyl amine in presence of NaOH.  Various curcuminoids were synthesized by treating acetyl acetone and various substituted aldehydes in the presence of boric anhydride and ethyl acetate at room temperature. Crude products then extracted with various suitable organic solvents and recrystallized from methanol. The synthesized products were checked for purity by TLC. All the products were characterized by H1 NMR, MS, FT-IR spectroscopies.

Keywords Curcuminoids, Acetyl acetone, vanillin, epichlorhydrin, boric anhydride

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