Molecular mechanisms of inflammsome activation remains an interesting area of research. Recently, polymer oxides provided new insight into therapeutic approach. Therefore, this work aims to investigate the chemical preparation of novel nanomaterials in aqueous solution and their biological activities were studied in vitro. Polymer oxides nanocrystals (PONK) were prepared using sol gel method. Size and morphology of the crystals were examined using Atomic force microscopy (AFM). The spectroscopic results showed absorption in a blue region. based on the experimental results, polymer oxides show highly anti-inflammatory effects evidenced by specific inhibition of interleukin one beta production and release in vitro using Elisa, western blotting, and RT PCR.