Abstract The discovery of cisplatinas new metallodrugs shows higher efficiencies and lower side effects. In this work, 2-(4-clorophenyl)-4,5-diphenyl-1H-imidazole schiff base ligand and complexes of 2-(4-clorophenyl)-4,5-diphenyl-1H-imidazoleligand with Co(II), Ni(II) and Cu(II) ions were synthesized. 2-Dimensional TLC results one node that reveal the ligand is pure. The melting point of the ligand is 197-199°C. Identification the result of 2-(4-clorophenyl)-4,5-diphenyl-1H-imidazole is showed by 1H-NMR spectrometer.All complexes were characterized by analytical techniques and their molecular formulae established. The result showed that Co(II) complex and Ni(II) complex has octahedral geometry and Cu(II) compound has tetrahedral geometry. Their cytotoxic activity against cancer celllinesHuman Colorectal (HCT 116) was tested. The complexes provide good activity (IC50=17.9 mM for Co(II)complex, 29.6 mM for Ni(II) complex and 16.5 mM for Cu(II)complex.