Abstract Schiff bases are the compounds which are mainly formed by the condensation of the aldehydes and amines. Benzothiazole is a privileged heterocyclic scaffold having a benzene ring fused with a five membered thiazole ring. A few Substituted 1, 3-benzothiazole derivatives are an important class of heterocyclic compounds. In recent years heterocyclic compounds analogues and derivatives have attracted strong interest due to their biological and pharmacological properties. Benzothiazole moiety is very small but it posses different biological activities. Not only benzothiazole but its different substituted derivatives also give different biological activities. Researches carried out on benzothiazole moiety had established promising antimicrobial activities like antimalarial, antifungal, anti tubercular, antiviral as well as antitumor, analgesic and anti-inflammatory activities.