Abstract In the past decades, crop diseases and human health is always at stake and the emerging problem on the use of synthetic antipathogens and medicine is one of the most difficult to combat. This current research was carried out to determine the phytochemical constituents and the inhibitory activities of Samanea saman (Jacq.) Merr. pods. Eight preliminary phytochemical tests was done which includes, test for alkaloids saponins, flavonoids, tannins, glycosides, steroids, terpenoids and resins. Powdered pods were subjected to ethanol and aqueous extraction. Alkaloids, saponins, tannins, glycosides, steroids, terpenoids and resins was found present on both extracts, however absence of flavonoids on both extraction was observed.The inhibiting capability of the S. saman pods revealed that there is a significant effects on the inhibitory effects against in-vitro bioassay of F. oxysporum, known to cause wilts on crops and the two bacterial pathogens E.coli and S.aureus via disc diffusion method.