Abstract In order to ensure the optimum therapeutic effect of drug it is necessary to prepare the proper dosage form. Solubility is a significant physicochemical factor affecting absorption of drug and its therapeutic effectiveness. Poorly water soluble compounds have both solubility and dissolution related problems which can dramatically affect their bioavailability resulting in reduction of their therapeutic efficacy. To overcome such a problem solid dispersions of poorly soluble drugs like Cefixime, Valsartan and Ibuprofen were prepared and evaluated. Suitable carriers such as PVP K30 and HMPC etc. in different ratios were chosen. They were prepared by physical mixing and kneading method. The standard curves were prepared for cefixime, ibuprofen and valsartan in methanol. The release studies were carried out and compared. The results showed a marked increase in release of the drug from solid dispersions compared to the drug in its pure form. The percentage of the drug released for Ibuprofen increased from 12.78 to 52.4% (1:1 ratio), 70.2% (1:2 ratio) and 68.2% (1:3 ratio). The use of cefixime with hydroxypropymethylcellulose (HPMC) greatly improved the solubility of the drug and enhanced its dissolution rate. The percentage of the drug released increased from 13.2 to 31.4% (1:1 ratio), 34.9% (1:2 ratio) and 43.9% (1:3 ratio). The ratios which showed the best release were considered as the optimized formulations.