Formulation and Evaluation of Risperidone Fast Disintegrating Tablets by Using Co- processed Superdisintegrants

Abstract In the present work, an attempt has been made to develop fast disintegrating tablets of Risperidone. Novel method of co processed super disintegrates technology was employed to formulate the tablets. All the formulations were prepared by direct compression method using 8mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F8 formulation showed maximum % drug release i.e., 101.4 % in 2 min hence it is considered as optimized formulation. The F8 formulation contains CP3 as super disintegrate in the concentration of 20 mg. (CP 3 contains SSG and CCS in 1:3 ratio).

[Full Text: PDF]

Updated: April 26, 2017 — 4:12 pm