Design, Formulation and Evaluation of Fast Disintegrating Tablets of Febuxostat

Abstract Febuxostat, is a medication used in the treatment of chronic gout and hyperuricemia. Febuxostat is a non-purine xanthine oxidase. It is a BCS class II drug. It exhibits poor bioavailability about 49% which is attributed to its poor bioavailability and poor solubility. The present work was aimed to overcome its limitation of poor solubility. Drug and beta cyclodextrin complexes were prepared in the ratio 1:1 and 1:2. Studies show that solubility was better for 1:2 ratio (855.20 µg/ml) as compared to that of pure drug (10.50 µg/ml). Tablets were prepared by using ingredients such as Beta-Cyclodextrin, Crospovidone, Locust Bean Gum, Crosscarmellose, Microcrystalline Cellulose, Mannitol, Magnesium Stereate, Sodium Saccharine.[Full Text: PDF]

 

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