Category: Uncategorized

In Search of the Truth about the Quality of Mueller Hinton Agar and Tested Antimicrobial Discs

Abstract Objectives: The main goal of the provided experiments was to test the influence of the used in the Disc Diffusion Method (DDM) Mueller Hinton agar (MHA) and to establish its reflection on the interpretation of the antimicrobial test. Methods: This study is based on developed microbiological methodology and outworked protocol for qualification of the […]

Ethno and Modern Pharmacological Profile of Baheda (Terminalia bellerica): A Review

Abstract Terminalia bellerica is an important traditional Indian medicinal plant used in various ailments and rituals. The use of different parts of this plant like leaves and fruits as a medicament for treatment of various conditions is well documented in literature. Terminalia bellerica Roxb. (Combretaceae) is one of the ingredients of ayurvedic purgative medicament of […]

Preliminary Phytochemical and Antibacterial Screening of Crude Methanolic Extracts of Some Plants against Tested Bacterial Isolates

Abstract Infectious diseases caused by bacteria, fungi, parasites and viruses are still a major threat to public health. Their impact is particularly large in developing countries due to the relative unavailability of medicines and the emergence of widespread drug resistance. This has lead to the search of new antimicrobial agents mainly among plant extracts. As […]

Bioactive Compounds from Marine Streptomyces Sp. by Gas Chromatography-Mass Spectrometry

Abstract The objectives of this study were analysis of the secondary metabolite products from extract of marine Streptomyces sp. strain ND7a which isolated from sponges at Ha Tien Sea, Kien Giang province, Vietnam. Six bioactive compounds were identified in the organic solvent hexan-aceton and aceton-methanol. The identification of bioactive chemical compounds is based on the […]

Evaluation of Local Processing of Tapioca and its Effect on the Starch and Cyanide Contents

Abstract Tapioca constitutes one of the staple foods prepared in different forms for consumption by many African dwellers, including Nigeria. It is a processed food from Manihot esculenta (cassava), rich in carbohydrate and contains linamarin that produces the toxic compound, hydrogen cyanide (HCN). Samples were collected from six selected areas: Bua-Yeghe, Sogho, Ebubu, Igbodo, Baa-Goi […]

Bioactive Compounds from Marine Fungus Penicillium citrinum Strain ND7c by Gas Chromatography-Mass Spectrometry

Abstract The objectives of this study were analysis of the secondary metabolite products from extract of marine Penicillium citrinum strain ND7a which isolated from sponges at Ha Tien Sea, Kien Giang province, Vietnam. Sixteen bioactive compounds were identified in the organic solvent hexan-aceton and aceton-methanol. The identification of bioactive chemical compounds is based on the […]

Review Study on the Physiological Properties and Chemical Composition of the Laurus nobilis

Abstract The Laurus nobilis is one of the plants of the lauraceae species which has many physiological properties. It is an antimicrobial, antifungal, anti-oxidant and other properties that make laurel oil and its compounds a good and a valuable substance for use in pharmaceuticals and cosmetics, chemically contains many compounds such as: turbines, anthocyanins coumarins […]

Synthesis and Characterization of Cdo Nanoparticles Prepared via Chemical Precipitation and Sol-Gel Techniques

Abstract In this paper, two kinds of preparation methods were used to synthesize CdO nanoparticles. NaOH and citric acid were severally mixed with cadmium nitrate to produce the nanocatalyst via precipitation and sol-gel auto-combustion method respectively. The reactants were either ultrasonicated or mechanically shear-mixed for comparison. And the synthesised samples were characterized for their size […]

A Consensus Review on Fast Disintegrating Tablets

Abstract Oral route is the most preferred route for administration of various drugs because it is regarded as safest, most convenient and economical route. Recently researcher developed the fast disintegrating tablets with improved patient compliance and convenience. Fast disintegrating tablets are solid dosage forms which dissolve rapidly in saliva without chewing and additional water. Fast […]

Phytochemical and In Vitro Antibacterial Properties of Leaves of Some Selected Plant Species in Maiduguri, Nigeria

Abstract The phytochemical analyses of the leaves of some selected plants species (Amaranthus caudatum, Brasica oleracea, Ipomea batata, Manihot esculenta and Telfera occidentalis) and in vitro antimicrobial activities on some bacteria species were determined using aqueous and ethanol solvents in Maiduguri, Nigeria. Analysis revealed the presence of tannin, cardiac glycoside, saponin, glycoside, flavonoid and tapenoid […]

DNA Binding Studies of Platinum(II) and Palladium(II) Complexes with Planar Tridentate 2,6-bis(N-R-benzimidazol-2-yl)pyridine Ligands

Abstract Four new complexes of platinum(II) and palladium(II) with planar tridentate ligands, 2,6-bis(N-H-benzimidazol-2-yl)pyridine (L-H), and 2,6-bis(N-methyl-benzimidazol-2-yl)pyridine (L-Me), as [Pt(L-H)Cl]Cl (1), [Pd(L-H)Cl]Cl (2), [Pt(L-Me)Cl]Cl (3), and [Pd(L-Me)Cl]Cl (4) have been synthesized and fully characterized by means of CHN, FT-IR (ATR), 1H NMR, and ESI or MALDI TOF MS techniques. The DNA-binding behaviors of all complexes have […]

Synthesis and antiviral activity of 3-substituted phenyl-6-substituted phenyl (1,2,4) triazolo (4,3-b) pyridazin

Abstract A series of 3-substituted phenyl -6-substituted phenyl (1,2,4) triazolo (4,3-b) pyridazine has been synthesized. An appropriate aromatic hydrocarbon reacts with succinic anhydride in presence of AlCl3   to yield β-aroyl propionic acid. The corresponding acid was cyclised with hydrazine hydrate to give 6-(substituted aryl)-2, 3, 4, 5-tetrahydro-3-pyridazinone, which was heated on steam bath with phosphorous […]

Synthesis and Properties of UV Curable Waterborne Polyurethane Acrylate Based on Modified Castor Oil

Abstract In this study, castor oil was modified to prepare hydroxyethyl methyl acrylate (HEMA) capped waterborne polyurethane-acrylate (UV-PUA) via in-situ and anionic self-emulsifying method. Ultraviolet (UV) curable UV-PUA film was obtained with IRGACURE 819 as photoinitiator. The properties of UV-PUA dispersions, such as appearance, viscosity and average particle size were investigated. The structure and thermal […]

Investigation of Reverse Phase HPLC Method for Determination of Nimodipinein Pharmaceutical Dosage Form using Nanoparticles Modified with Cetyltrimethylammonium Bromide

Abstract A rapid and sensitive high-performance liquid chromatogaphic method was developed for the estimation of nimodipine in pharmaceutical dosage forms. Nimodipine was chromatographed on a reverse phase C- 18 column in a mobile phase consisting of acetonitrile and water in the ratio of 58:42 (v/v). The mobile phase was pumped at a flow rate of […]

Fabrication of Colon Drug Delivery by Nanoparticle Drug Intended of Carboxymethyl Cellulose Sodium

Abstract Double walled polymer with a Core of mixture of nanoparticle of carboxymethyl cellulose sodium salt and a model drug olsalazine [3,3´-azobis(6-hydroxy benzoic acid)] as an azo derivatives of 5-aminosalicylic acid and an external coat of cross-linked copolymers of N-vinyl-2-pyrrolidinone and methacrylic acid with various amounts of cross-linking agents. Cubane-1,4-dicarboxylic acid linked to two HEMA […]

Determination of Natural Radioactivity Concentration Levels in Soil Samples in Odigbo Local Government Area

Abstract The aim of this study was to evaluate the level of natural radioactivity  concentrations of 238U, 232Th and 40K in the surface (0-5cm) soil samples collected from Odigbo in the Southwestern region of Nigeria. The surface soils were collected along the streets of this city. The activity concentrations of naturally-occurring radioactive materials in the […]

Synthesis of novel 2-(4-clorophenyl)-4,5-diphenyl-1H-imidazoleand its cobalt(II), nickel(II), copper(II) and Cu(II) complexes

  Abstract The discovery of cisplatinas new metallodrugs shows higher efficiencies and lower side effects. In this work, 2-(4-clorophenyl)-4,5-diphenyl-1H-imidazole schiff base ligand and complexes of 2-(4-clorophenyl)-4,5-diphenyl-1H-imidazoleligand with Co(II), Ni(II) and Cu(II) ions were synthesized. 2-Dimensional TLC results one node that reveal the ligand is pure. The melting point of the ligand is 197-199°C. Identification the […]

Assessment of In-vitro and In-vivo Bioactivities Potential of Some Egyptian Wild Plants as Anti-Ulcerogenic Effect on male albino rats

Abstract Background: There is an abundance of herbal medicines that may introduce to cure the human patient for different syndromes with mild side effect. This study aimed to investigate In-vitro and In-vivo bioactivities potential of some Egyptian wild plants as anti-ulcerogenic on male albino rats. Polyphenols constitute a distinct group of natural compounds of medicinal […]

African Traditional Antimalarials: A Review

Abstract Traditional herbal medicines have been used to treat malaria for thousands of years in various parts of the world especially Africa.  This review addresses medicinal plants used to treat malaria in traditional medicine from many Africa countries and compare popularly used native species, antimalarial activity of extracts and isolated substances. New drugs have to […]

The Effect of Salt Concentration and Incubation Time on Protein Content and Bacteria Number of Cakalang Fish (Katsuwonus pelamis) Ina sua

Abstract Ina sua is a traditional salted fish product belongs to Teo Nila Sarua (TNS) community, Maluku, Indonesia. The first aim of this study is to find out the effect of salt concentration on protein content and bacteria number of cakalang fish (Katsuwonus pelamis) Ina sua. Three salt concentrations (10%, 20% & 30%) are used […]

Synthesis and Antimicrobial Activity of Phenol-derived Mannich Bases

Abstract Using p-acetamidophenol as an active hydrogen component, two Mannich bases: N,N-[(5-acatamido-2-hydroxy)benzyl]ethylamine(I) and N-[(5-acatamido-2-hydroxy)benzyl]ethylamine(II) were synthesized via a general synthesis protocol. .The structures of the target molecules were elucidated by a combination of spectral techniques (UV, IR, 1H NMR and MS). The Mannich bases were evaluated for their antimicrobial activity against seven standard human pathogens. […]

GC-MS analysis and Antimicrobial Activity of Sudanese Jatropha curcas L. (Eupharbiaceae) Fixed Oil

Abstract Jatropha curcas seed oil was studied by GC-MS. The oil was also evaluated for antimicrobial activity. Twenty two components were detected by GC-MS analysis. Main constituents are: Z,Z-9,12-octadecadienoic acid methyl ester (37.56%); Z-9-octadecenoic acid methyl ester (26.03%%); hexadecanoic acid methyl ester (19.09%); methyl stearate (13.20%). The antibacterial activity of the oil was evaluated via […]

Anti-nutrients Composition of Fluted Pumpkin Leaf Grown in Different Geoponic Media

Abstract The anti-nutrient compositions of fluted pumpkin leaf grown in three different geoponic media were quantified. These media were white-sand (WS), humus soil (HS) and sawdust (SD). The anti-nutrients composition of matured pumpkin leaf assessed were alkaloids, flavonoids, saponins, hydrogen cyanide, trypsin-inhibitor, oxalate, tannins and phytate. Standard analytical methods were followed in the determination of […]

Preparation and Evaluation of Proliposomes Containing Glibenclamide

Abstract The aim of the present study was to investigate the proliposome as potential carriers for efficient oral delivery of GIibenclamide in order to improve its bioavailability. The Glibenclamide loaded proliposomes were prepared using hydrogenated soyphosphatidylcholine (HSPC), cholesterol and using sorbitol as the carrier in varying ratios and characterized for entrapment efficiency, vesicle size, The […]

Glycogen Storage Disease Type IV: A Case Report

Abstract   Glycogen storage disease type IV (GSD-IV) “Andersen’s disease” is an autosomal recessive disorder due to a deficiency of glycogen branching enzyme (GBE). We report a four years old female patient with glycogen storage disease type-IV who exhibited an abdominal distension and failure to thrive since the age of 9 months. The patient showed hepatosplenomegaly […]

Genus Deguelia: Chemistry, Chemotaxonomy, Ethnopharmacology and Pharmacological Characteristics – A Review

Abstract The genus Deguelia comprises the American species previously included in Derris Lour. Millettia Wight & Arn. and Lonchocarpus subg. Phacelanthus Pittier. Considering the need of systematic definition to the genera Derris, Deguelia and Lonchocarpus, and also the economic importance presented by several species within these genera, which produces rotenone or deguelin (natural insecticides widely […]

Adsorption of Lead in Aqueous Solution using Montmorillonite-silica Nanocomposite

  Abstract In this study, the locally available materials which include; montmorillonite clay and rice husks were used to synthesize montmorillonite-silica nanocomposite as adsorbent in removal of lead from aqueous solution. Fourier transform infra-red (FTIR), was used to characterize the adsorbent. Batch method of adsorption was employed in the study and parameters that influence the […]

Comparative Studies on the Effects of Organic and Inorganic Fertilizers on Growth factors, Dry matter yield and Phosphorus (P)-Uptake of Cashew Nut Seedlings

Abstract A greenhouse study was carried out at Cocoa Research Institute of Nigeria (CRIN), Ibadan to investigate   growth factors, dry matter yield and P-uptake of cashew seedlings of different nut sizes using organo-mineral and inorganic fertilizers. The fertilizers were applied at rates of 0, 10, 20 ton/ha and 0, 10, 20kg N/ha for seven treatments […]

Comparable effects of the different extracts of the same plants on blood pressure and vascular tone

Abstract Many people have suffered from hypertension and comorbid diseases for long years. Before the discovery of antihypertensive drugs, plants were used in folk medicine to treat hypertension. Nowadays, sufferers still prefer medical plants versus drugs. Furthermore, researchers focus on herbal drugs. There are lots of researches about plants which are used for cardiovascular diseases […]

In vitro Antioxidant Activity and Phytochemical Evaluation of Five Medicinal Plants Extract

Abstract The objective of this study is to determine the antioxidant activity and phytochemical constituents of methanol extract of five medicinal plants. Preliminary phytochemical screening was determined using modified method of Harbone while quantitative phytochemical test was carried out using HPLC technique method of AOAC. Preliminary phytochemical screening revealed the presence of flavonoids, phenols alkaloids, […]

Isolation of Phytochemical Constituent, Characterization and Pharmacognostic Studies of Stem and Leaves of Alangium Salvifolium Wang

Abstract Phytochemical constituent from Ethanolic Extract of Alangium Salvifolium [EEAS] was isolated using column chromatography and characterized by various spectroscopic studies such as Infrared (IR) spectra, Nuclear Magnetic Resonance (NMR) spectra and Mass Spectral studies. Results of various spectroscopic studies were interpreted and the interpreted results suggested that the isolated compound may be Di-demethoxyalanginol. Further […]

Analysis of Phytochemical Constituents, Anthelmintic and Insecticidal Properties of Leaf Extracts of Andrographis paniculata

Abstract Andrographis paniculata is an annual herb distributed in tropical countries and it is widely used in traditional medicines. The present study was aimed to investigate the presence of phytochemical constituents, anthelmintic and insecticidal properties of leaf extracts of A. paniculata. The highest percentage of extractive of 24.6% was observed for ethyl acetate extract and […]

Natural Occurring Thiirane Containing Compounds: Origin, Chemistry, and their Pharmacological Activities

Abstract This mini review describes research on rare and unusual natural and/or semi-synthetic thiirane-containing compounds isolated from plant, fungi, bacteria, and invertebrates. About 40 biologically active epithio metabolites demonstrate confirmed pharmacological activity, including antitumor, antimicrobial, and antibacterial effects. The structures, origin, and biological activities of epithio metabolites are reviewed. Utilizing the computer program PASS, some […]

Synthesis of Silver Nanoparticles Mediated by Stem Extract of Anredera cordifolia and Study of their Antimicrobial Properties

Abstract In this study, we synthesize silver nanoparticles using Anredera cordifolia stem extract as a reducing agent. We evaluate the antimicrobial properties of these nanoparticles against gram negative bacterial strain (Escherichia coli) and gram positive bacterial strain (Staphylococcus aereus). It took less than 10 minutes after mixing stem extract with silver nitrate solution for silver […]

Formulation and Characterization of an Antibacterial Cream from Lantana camara Leaf Extract

Abstract Purpose: The aim of the study was to evaluate the antibacterial activity of the ethanolic extract of the plant Lantana camara leaves against Staphylococcus aureus and E. coli species. Also to formulate effective and stable herbal antibacterial cream evaluates its physical and antibacterial properties. Methods: Disk diffusion method was used to assess antibacterial activity […]

Computational Prediction of Pharmacokinetic, Bioactivity and Toxicity Parameters of Some Selected Anti arrhythmic Agents

Abstract Many pharmacological agents are available for the treatment of cardiac arrhythmias. Arrhythmia may be classified on the basis of rate (bradycardia and tachycardia), mechanism (automaticity, re-entry, triggered) or duration (isolated premature beats; couplets). The treatment approach to arrhythmia depends firstly on whether or not the affected person is stable or unstable. This research investigation […]

Anti-Hepatitis B Viral Potentials of Ethanolic Stem Bark Extract of Vitex doniana and Lophira alata in Wistar Rats

Abstract Anti-hepatitis B viral activity of ethanol stem bark extracts of Vitex doniana and Lophira alata in Wistar rats was investigated. Forty-two (42) humanized albino rats were used for the study. The animals were divided into six (6) groups of seven (7) animals each. Groups II-VI were inoculated with hepatitis-B virus at the concentration of […]

Preparation of Microparticles of Polycaprolactone Containing Piroxicam to use in Chronic Inflammatory Diseases

Abstract The microparticles containing piroxicam were produced by the oil-in-water emulsion-solvent evaporation technique, and characterized by microscopy, loading efficiency, size distribution and polydispersity index, in vitro drug release and release kinetics. A total of 20 formulations were prepared and characterized. Microparticles presented micrometric size of 1.026µm to 3.541µm, distribution homogeneous with PDI below 0.35 with […]

Lead Poisoning causes Histoarchitectural Disruptions in Blood Marrow, Brain Regions and Muscles Histological Observations of Lead Poisoning Effects on Vital Body Tissues of Murine Models: Part I

Abstract The damaging effects of lead poisoning effects to various organs of the body have been severally reported; as well as the health complications they produce. There are however relatively few reports on the nature of such effects on body tissues- histology, most publications have rather addressed the resulting complications. The proper understanding of the […]

Pharmaceutical Process Validation Approach for Extended Release Tablets: An Overview

Abstract Validation is an integral part of quality assurance; it involves the systematic study of systems, facilities and processes aimed at determining whether they perform their intended functions adequately and consistently as specified. A validated process is one which has been demonstrated to provide a high degree of assurance that uniform batches will be produced […]

Foliar Blight Disease Occurrence on Zea maize L. Cropin Tehsil Samahni Area of Azad Jammu and Kashmir, Pakistan

Abstract Zea maize L (corn) is prevalent and agronomic crop being ubiquitously cultivated in many areas of  Tehsil Samahni of Azad Jammu and Kashmir (Pakistan), This is serving as staple food for mountainous communities of the area. The corn crop is being damaged due to many biotic and abiotic parameters. Fungal attack culminating into different […]

Sudanese Petroselinum crispum Fixed Oil: GC-MS Analysis and Antimicrobial Activity

Abstract Information on plants used traditionally in Sudanese system of medicine is very scarce. Hence this study was undertaken to investigate the chemical constituents of Petroselinum crispum fixed oil and to evaluate its potential antimicrobial activity. 62 components were detected by GC-MS. Major components are: apiol (36.44%), 9-octadecenoic acid methyl ester (27.17%), 4-Methoxy-6-(2-propenyl)-1,3-benzodioxole12.12%) and 9, […]

Bioadhesive Ocular Inserts of Norfloxacin for the treatment of ocular E. coli infection: Development and in vitro evaluation

Abstract The purpose of the present research was to formulate ocular inserts of norfloxacin along with bioadhesive polymers to sustain drug release and assess its antimicrobial potential against E. coli, in vitro. Ocular inserts of norfloxacin were prepared by film casting method using bioadhesive polymers HPMC/ SCMC/ sodium alginate/ chitosan/carbopol 934 and PVP K30 as […]

Design and In-vitro Evaluation of Enteric Coated Pulsatile Drug Delivery System of Zileuton Tablets

Abstract In the present research work pulsatile drug delivery system of Zileuton tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by 30% concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated tablet formulations were […]

Chemical Composition and Antioxidant Properties of Kenari (Canarium indicum) Nut

Abstract Kenari (Canarium indicum L) belongs to Burseraceae family and grows abundantly in Indonesia especially in Eastern Indonesia. The kernel is often called kenari nut. The nut contains high amount  of lipid and various chemical substances, such as protein, phenolic compound, and tocopherol. The chemical composition is affected by some factors, especially area of origin. […]

Biodiesel Production from Methanolysis of Refined Vegetable Oil through KOH/zeolite Catalyst

Abstract In this study, bentonite based catalyst was prepared by impregnation methods in potassium hydroxide solution (35 wt.%). The catalysts were calcined at 500  for 3 h. The best reaction conditions in the presence of KOH/bentonite were determined while modifying the catalyst to soybean oil ratio and the reaction time. Bentonite was proved to enhance […]

Investigation of Antioxidant, Biological and Acidic Properties of New 3-Alkyl(Aryl)-4-(3-acetoxy-4-methoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones

Abstract Some novel 3-alkyl(aryl)-4-(3-acetoxy-4-methoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (4a-h) were synthesized from the rections of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2a-h) with 3-acetoxy-4-methoxybenzaldehyde (3). The new eight compounds were characterized using by elemental analyses and IR, 1H-NMR, 13C-NMR and UV spectral data. In addition, the synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. Antibacterial activity of […]

Antioxidant Status in Aluminum Intoxified Male Wistar Albino Rats

Abstract Oxidative stress is associated with increased production of oxidizing species (from reactive oxygen species or transition metals) or a significant decrease in the effectiveness of antioxidant defense. Aluminum toxicity was investigated using antioxidant status in serum of male Wistar albino rats. Antioxidants studied in this work include superoxide dismutase (SOD) and glutathione S- transferase […]

Preparation of a drug carrier through supramolecular hydrogel based on poly(ethylene glycol) methyl ether- folic acid – α-cyclodextrin for controlled delivery of Doxorubicin

Abstract This study is aimed at developing novel, inexpensive hydrogels for containing drug and with the potential for targeting cancer cells in vitro. In this work, Folic acid has been conjugated with α-Cyclodextrin and then used as a building block for constructing novel supramolecular hydrogels together with Poly(ethylene glycol) methyl ether in aqueous solutions. Resultant […]

Determination of Secondary Metabolites and Biological Potential of Gnetun africanum (Okazi) Leaves

Abstract The ethanol, methanol, n-hexane and aqueous extracts of Gnetum africanum leaves were investigated for phytochemical studies and antibacterial assay using Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Penicillium chrysogenum and Aspergillus fumigatus. The phytochemical analysis revealed the presence of tannins, saponins, glycosides, steroids in varying amount and the absence of flavonoids and anthraquinones. The antimicrobial […]

Assessment of the Phytochemical constituents and in-vitro antibacterial activity of Vernonia amygdalina extracts on someclinical isolates

Abstract Antimicrobial resistance is on the rise and efforts are consequently being strengthened towards the search and improvement of sturdier antimicrobial agents with expectant safety and efficacy. This study was conducted to determine the phytochemical analysis and antibacterial activity of Vernonia amygdalina (bitter leaf) extracts obtained from a market in Sokoto state Nigeria on some […]

Effect of Various Starches on the Physicochemical and Sensory Characteristics of Tomato Paste

Abstract This research had been carried out to identify the effect of starches which are one of the most important value added food ingredient used in numerous food industries, on the physicochemical and sensory characteristics of tomato paste. In this study four types of starches including potato starch, rice starch, yam starch,  and corn starch […]

Formation and phase transition enthalpies for captopril

Abstract Combining solution calorimetry data with quantum chemical thermochemistry, a series of thermochemical parameters for captopril were obtained, as follows:  ΔsolHθ (in water) = 12.26 ± 0.4kJmol-1; ΔsolvHθ= -53.43kJmol-1;ΔcrgHθ = 65.70 kJmol-1, ΔcrlHθ= 19.53kJmol-1;ΔlgHθ= 46.17 kJmol-1;ΔfgHθ= -623.10 kJmol-1, ΔflHθ = -576.93 kJmol-1;   ΔfcrHθ= -557.40  kJmol-1; Cv= 231.72 JK-1mol-1andCp= 240.03 JK-1mol-1. [Full Text: PDF]

Effect of Chronic Smoking on Mouse Corpus Cavernosum and Protector Role of Alpha-linolenic Acid

Abstract Studies have shown the antioxidant and anti-inflammatory activity of alpha-linolenic acid, one of the omega 3 fatty acids found abundantly in linseed oil. Cigarette smoke causes impotence as it contains many harmful components and increases oxidative stress. Therefore, we planned to investigate whether or not alpha-linolenic acid has protective effect against impotence due to […]

Antibacterial Potentiality of Water Extract of selected Honey Samples on Some Clinical Isolates

Abstract The present study was carried to evaluate antibacterial activity of water extracts of honey against some selected bacteria (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and pseudomonas aeruginosa) using microdilution method (MIC) at different concentrations (100-0.195mg/ml) and well diffusion method (200 mg/ml). The inhibitory potency of the honey from different sources varied on the test […]

Synthesis and Comparison Spherical and Bars Iron Oxide Nanoparticles: Providing Reaction Mechanisms

Abstract Nanomaterials, especially inorganic nanomaterials such as metal, metal oxide, metal sulfate, quantum dots, et al. With the basic properties of quantum dots significantly in the development of biomedical, catalytic, fuel cells, sensors and magnetic data storage were attracted. The term nano-crystal can be designed and synthesized nano-crystal morphology and composition to the understanding and […]

Comprehensive Dossier on Ayurvedic Medicinal plant Aegle marmelos (L.) Corrêa. : A Review

Abstract Aegle marmelos (L.) Corrêa is a medicinal and dietary plant species with traditional and folk uses since millennia. Numerous numbers of phytochemicals present in the plant are responsible for diversified pharmacological activities. Brief discussions on plant pharmacognosy, pharmacology are included in this article. The authors of this review put an immense emphasis on phytochemicals […]

Adsorptive removal of Bisphenol A from aqueous solutions by Pistacia atlantica: isotherm and kinetic Studies

Abstract The aim of this study is to investigate the possibility of Pistacia atlantica Biomass as an alternative adsorbent for Bisphenol A (BPA) removal from aqueous solution. The effect of various parameters including contact time, solution pH, adsorbent dosage and Bisphenol A concentration was investigated in this experimental-lab study, Also, the isotherm and kinetic studies […]

Method Development and Validation for Simultaneous Estimation of Lamivudine and Zidovudine by RP-HPLC

Abstract A new, accurate, rapid and effective isocratic reverse-phase high performance liquid chromatographic (RP-HPLC) method was developed, optimized and validated for the estimation of Lamivudine (LAM) and Zidovudine (ZID) in bulk and pharmaceutical dosage forms. The drugs were estimated using Shiseido C18 (250 mm x 4.6 mm, 5 µm particle size) column. A mobile phase […]

Production of Cephalosporin C from Acremonium chrysogenum, and its Antimicrobial Activity against Some Pathogenic Bacteria

Abstract The Production of cephalosporin C by Acremonium chrysogenumin flask contain fermentation medium, after that its extraction, purification and estimation was performed by Spectrophotometric Method. The antimicrobial activities of both the crude and purified cephalosporin C were performed against the test organisms by Agar Well Diffusion Method. Agar well diffusion method and the inhibition zones […]

Antibacterial and Anatomical Study of Capparis decidua L. from Different Localities of District Bhimber Azad Jammu and Kashmir, Pakistan

Abstract The plant Capparis decidua L. belongs to family Capparidaceae and its stem and fruit were extracted successively with four organic solvents viz. petroleum ether, chloroform, ethanol, and distil water. These crude extracts were assessed for antibacterial activity against two gram positive bacteria i.e. Staphylococcus aureus and Bacillus subtilus and two gram negative bacteria i.e. […]

Selective s-alkoxycarbonylation of isomeric 5-pyridyl-1,3,4-oxadiazoles and antimicrobial activity of the synthesized compounds

Abstract Selective S-alkoxycarbonylation of isomeric – 5-(2-pyridyl)- (1), 5-(3-pyridyl)- (2), and 5-(4-pyridyl)-1,3,4-oxadiazol-2-thiones (3) have been studied and novel series of S-substituted derivatives (7-15) have been synthesized and characterized by physical methods of research. No formation of the amides – N-substituted derivatives (A) was observed. The antimicrobial tests indicated that the 2-alkyloxycarbonylthio-oxadiazole derivatives exhibited a remarkable […]

Control of erwinia spp. isolated from star-of-bethlehem (ornithogalum spp.) using actinomycetes and antiserum prepared from the bacteria using rabbit

Abstract Erwinia spp. causes soft rot in Ornithogalum spp., a flower grown purposely for export in Kenya. As a result the pathogen pauses a great risk to the economy of the country. This study aimed at isolating actinomycetes and Erwinia spp. from the soils of Menengai crater and infected Ornithogalum spp. respectively. In addition, the […]

Short Review on Hepatitis B

Abstract Hepatitis B virus currently infects more than 400 million people worldwide. The epidemiology of Hepatitis b virus infection is geographical diverse with population .Exploring the burden of chronic HBV infection this paper present a complete life cycle and biology of Hepatitis b virus in human body along with the symptoms of Hepatitis .it also […]

Volatile Organic Compounds: Classification, Sampling, Extraction, Analysis and Health Impacts

Abstract Volatile organic compounds are those that are present in the air having the low boiling points and easily evaporated.  These are classified into three categories: volatile, semi-volatile and very volatile compounds. They can be collected by the passive and air sampling or grab and integrated sampling.  Mostly, they are collected in tedlar bags made […]

Phytochemical screening and anti- hepatotoxic effect of ethanolic root extract of Terminalia macroptera (guill & perr) on induced liver injury Wister rats

Abstract This paper reports the anti-hepatotoxic effect of the ethanol extract of the root of Terminalia macroptera (Guill and Perr) on carbon tetrachloride induced liver injury Wister rats. The animals were separated into five groups (A, B, C, D & E) consisting of three animals per group. The rats in group A were induced subcutaneously […]

Antibacterial and Anatomical Analysis of Calotropis procera (aiton) Dryand from Different Areas of District Mirpur, Azad JAMMU and Kashmir, Pakistan

Abstract This work presents antibacterial potential and anatomical investigation of Calotropis procera (Aiton) Dryand. Populations from different areas of Mirpur (Azad Jammu & Kashmir), Pakistan. In the research, three different areas (viz: Jarikus, Khaliqabad and Jatlan) were selected for population sampling (leaf parts) having no symptom of disease. Leaf powder was macerated in two solvents […]

Analgesic Activity of Quisqualis indica

Abstract The aim of the present study was designed to evaluate the analgesic activity of hydro alcoholic extract of Quisqualis indica Linn. leaves in wistar rats. The preliminary phytochemical screening of hydroalcoholic extract revealed the presence of alkaloids, carbohydrates, protein and amino acid, Saponins, glycosides, steroids, tannins, flavonoid and phenolic compounds. The peripheral analgesic activity […]

Disintegration of cerumen by using several natural cerumenolytic

Abstract Objective:  To find out the effects of various natural cerumenolytic products (e.g. ascorbic acid, α-tocopherol, rosemary, pine turpentine, pergamote, chestnut, rosehip and rose oils, and onion tincture) as well as distilled water and pure olive oil on the disintegration/dissolution of cerumen. Method: Cerumen was provided by mechanical removal from adult patients who attended the […]

Evaluation of in-vitro antioxidant, anti-inflammatory and diuretic potential of an ethanol extract of Sanseviera liberica leaves on wistar albino rats

Abstract Sansevieria liberica is a genus of floweringplant in the family of Asparagaceae, it is a medicinal plant mostly used in the herbal medicine to cure Abdominal pains, diarrhea, piles, asthma and snakebites. Cold ethanol extract in leaves of Sansevieria liberica were investigated on Anti-inflammatory and Diuretic activities in albino rats that were compared with […]

Production of Staphylokinase from Locally Isolated Lysogenic Staphylococcus aureus

Abstract Staphylokinase (SAK) is abacterial kinase produced by certain strains of Staphylococcus spp. It is a 14.5 kDa, consisting of 136 amino acids single polypeptidechain protein, which activates plasminogen to form plasmin and digest fibrin clots. SAK is a promising thrombolytic agent for the treatment of myocardial infarction. The present research was carried out to […]

Phytochemical screening and assessment of anti-sickling activity of total methanolic extracts of different organs of Curcuma longa L. (Zingiberaceae)

Abstract The aim of this study was (1) to compare the phytochemistry of different organs of Curcurma longa and assess the antisickling activity of C. longa different apart from the rhizome. In the present study, it was shown that besides the rhizome, other organs of this plant can also have interesting pharmacological properties. The chemical […]

Phytochemical Screening and Assessment of Antibacterial Activity of Total Aqueous Extracts of Afromomum melegeuta and African Indigenous Salt

Abstract The present study was conducted in order to justify the use of Afromomum melegueta seeds intraditional medicine for the treatment of certain infectious diseases and to assess the influence of heat during the extraction of the active principles of the drug decoction on the antibacterial activity. Then, a bacteriological study was conducted to compare […]

Assessment of Knowledge, Attitude and Practice of Hypertensive Patients towards the Non-Medical Management of Hypertension in Bishoftu General Hospital, 2016

Abstract The overall objective of this study was to assess the knowledge, attitude and practice of hypertensive patients towards the non-medical management of hypertension in Bishoftu General Hospital. A cross sectional study was conducted in Bishoftu General Hospital. Study was conducted on 281 hypertensive patients, out of which 114 males and 167 females were participated. […]

Essential Oil Composition of Chrysophthalmum schultz Bip. Genus from Turkey: A Study of the Chemotaxonomy

Abstract The Genus Chrysophthalmum is represented with three species in Flora of Turkey. In this study, The essential oils obtained from the aerial parts of Chrysophthalmum gueneri Aytac and Anderb, C. dichotomum Boiss. & Heldr. and C. montanum (DC.) Boiss. were analyzed by using GC and GC/MS. Fourty eight, sixty and forty five compounds representing […]

Effects of arbuscular mycorrhizal (AM) fungi on growth and nutrients uptake in Coleus aromaticus Benth.

Abstract The effect of arbuscular mycorrhizal (AM) fungi on root colonization, growth and nutrient content of (Coleus aromaticus) was investigated as complete randomized design with 4 treatments and 4 replications. Fungi inoculation treatments consisted: Gf (Glomus fasciculatum), Glomus margarita and NM (non-mycorrhizal). The results showed mycorrhizal plants significantly had higher shoot and root dry weight, […]

Effect of Soursop (Annona muricata l.) Leaf Extract on Sperm Toxicity Induced by Caffeine in Albino Rats

Abstract Extract of Annona spp. have been used for several medicinal purposes such as the management of diabetes and its complications, also as antioxidant and antimutagenic agents. Hence, the mitigating effect of soursop (A. muricata) leaf extract on sperm toxicity induced by caffeine was assessed on the weight of testes and epididymes, epididymal sperm count, motility, viability, […]

In vitro Anti-diabetic activity of Hydro-alcoholic Extracts of Leaves and Fruits of Ziziphus nummularia (Burm. F. Wight & Arn)

Abstract Hydro-alcoholic extraction of leaves and fruits of Ziziphus nummularia were prepared by Soxhlet and Maceration Method. Total Phenolic Contents of extracts were determined. Extract were also analyzed by FT-IR and HPLC. In vitro anti-diabetic activity of Extracts of Leaves and Fruits of Ziziphus nummularia (Burm. F. Wight & Arn) was evaluated. Among all extracts, […]

RP-HPLC method for the simultaneous determination of carbamazepine and nilotinib: Application solubility studies

Abstract A simple and precise high performance liquid chromatography method for concurrently determination of nilotinib (NTB) and carbamazepine (CBZ) in their pharmaceutical formulations was developed and validated. β-estradiol was used as an internal standard. The separation was carried out on Phenomenex Luna C18 RP-HPLC column using an isocratic elution at 1 mL/min flow rate with […]

Food dyes as blood cell dyes: An experimental and molecular modelling study to brilliant blue FCF and brown HT

Abstract In this work, the food dyes brilliant blue FCF and brown HT are experimentally tested as blood cell dyes. Quantum chemical calculations by Semi-Empirical (PM6) method were also performed. Calculated HOMO and LUMO orbitals energies, dipole moments, polar surface areas and entropies, suggested a higher affinity by the cells towards [blue CFC]-2 in comparison […]

© The Pharmaceutical and Chemical Journal Frontier Theme