Abstract Aqueous extract of Azadirachta indica is drunk by the Igbos as medicine for curing malaria fever. The dried leaves are kept at strategic places to drive away insects. In this research the effect of two solvent extracts of A. indicia were investigated on five micro-organisms that attack the skin. These micro-organisms include; Malassezia globosim, Atopic dermatitis, Propionibacterium acnes, Tricophyton microsporum and Staphylococcus aeurus. Disc agar diffusion method was used to assay for antimicrobial activity on the test isolates. The antimicrobial activity shows some inhibitory effects against the test organisms. The result shows that the ethanol and methanol extracts inhibited the growth of all the test organisms. The minimum inhibitory concentration (MIC) of both ethanolic and methanolic extracts for the five test organisms were found graphically. A. indica extracts were used to produce effective anticeptic soap and antifungal cream for the treatment of skin infection.