The aim of the present study was designed to evaluate the analgesic activity of hydro alcoholic extract of Quisqualis indica Linn. leaves in wistar rats. The preliminary phytochemical screening of hydroalcoholic extract revealed the presence of alkaloids, carbohydrates, protein and amino acid, Saponins, glycosides, steroids, tannins, flavonoid and phenolic compounds. The peripheral analgesic activity of hydroalcoholic extract of Quisqualis indica leaves (100 and 200 mg/kg p.o.) was studied using experimentally induced pain models: Tail flick method using analgesiometer and acetic acid-induced writhing effect in albino wistar rats of either sex. The plant extracts exhibited dose dependant analgesic activity in the all treated groups and the results were compared with that of standard drug (Aspirin 20 mg/kg, p.o.). Interpretation & conclusions: From our study, we concluded that the hydroalcolic extracts of Quisqualis indica Linn. leaves (100, 200 mg/kg, p.o.) possesses dose dependent, significant (P<0.05) analgesic activity against experimentally induced pain.